| Recognition | Identify patients with core temperature ≥40°C and CNS dysfunction (altered mental status, seizures, or coma) in the context of strenuous activity. | 12 |
| Rapid Cooling | Use cold water immersion (gold standard for exertional heat stroke) to rapidly decrease core temperature, aiming never to cool below 39°C to prevent overshoot hypothermia. | 12 |
| Adjunctive Cooling | If immersion is not feasible, employ conductive/convective cooling (cooling blankets) combined with evaporative techniques (mist with fans) for supplemental cooling. | 12 |
| Temperature Monitoring | Initiate continuous core temperature monitoring—preferably with a bladder or esophageal probe—to guide the cooling process accurately. | 12 |
| Fluid Resuscitation | Begin aggressive IV crystalloid rehydration to address the significant volume deficits common in exertional heat stroke and support hemodynamics. | 12 |
| Supportive Care | Manage agitation/shivering with short-acting benzodiazepines as needed, avoid routine intubation (since delays in cooling can worsen the prognosis), and monitor for complications. | 12 |